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Derivation of Transgene-Free Rat Induced Pluripotent Stem Cells Approximating the Quality of Embryonic Stem Cells.

Stem cells translational medicine - 1 Feb 2017

Li Shuping, Lan He, Men Hongsheng, Wu Yuanyuan, Li Ning, Capecchi Mario R, Bryda Elizabeth C, Wu Sen

Abstract excerpt

Although a variety of reprogramming strategies have been reported to create transgene-free induced pluripotent stem (iPS) cells from differentiated cell sources, a fundamental question still remains: Can we generate safe iPS cells that have the full spectrum of features of corresponding embryonic stem (ES) cells? Studies in transgene-free mouse iPS cells have indicated a positive answer to this question. However,...

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Identifiers

PMID: 28191784
DOI: 10.5966/sctm.2015-0390
PMCID: PMC5442795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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