Using an uncertainty-coding matrix in Bayesian regression models for haplotype-specific risk detection in family association studies.

Abstract excerpt

Haplotype association studies based on family genotype data can provide more biological information than single marker association studies. Difficulties arise, however, in the inference of haplotype phase determination and in haplotype transmission/non-transmission status. Incorporation of the uncertainty associated with haplotype inference into regression models requires special care. This task can get even more...

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