A Bayesian approach using covariance of single nucleotide polymorphism data to detect differences in linkage disequilibrium patterns between groups of individuals.

doi:10.1093/bioinformatics/btq327

Article

A Bayesian approach using covariance of single nucleotide polymorphism data to detect differences in linkage disequilibrium patterns between groups of individuals.

Bioinformatics (Oxford, England) - 15 Aug 2010

Clark Taane G, Campino Susana G, Anastasi Elisa, Auburn Sarah, Teo Yik Y, Small Kerrin, Rockett Kirk A, Kwiatkowski Dominic P, Holmes Christopher C

Abstract excerpt

MOTIVATION: Quantifying differences in linkage disequilibrium (LD) between sub-groups can highlight genetic regions or sites under selection and/or associated with disease, and may have utility in trans-ethnic mapping studies. RESULTS: We present a novel pseudo Bayes factor (PBF) approach that assess differences in covariance of genotype frequencies from single nucleotide polymorphism (SNP) data from a...

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A Bayesian approach using covariance of single nucleotide polymorphism data to detect differences in linkage disequilibrium patterns between groups of individuals.

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