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Article

Family-based association tests using genotype data with uncertainty.

Biostatistics (Oxford, England) - 1 Apr 2012

Yu Zhaoxia

Abstract excerpt

Family-based association studies have been widely used to identify association between diseases and genetic markers. It is known that genotyping uncertainty is inherent in both directly genotyped or sequenced DNA variations and imputed data in silico. The uncertainty can lead to genotyping errors and missingness and can negatively impact the power and Type I error rates of family-based association studies even if...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22156512
DOI: 10.1093/biostatistics/kxr045
PMCID: PMC3297829

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