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Article

Metabolomic profiling reveals a role for androgen in activating amino acid metabolism and methylation in prostate cancer cells.

PloS one - 1 Jan 2011

Putluri Nagireddy, Shojaie Ali, Vasu Vihas T, Nalluri Srilatha, Vareed Shaiju K, Putluri Vasanta, Vivekanandan-Giri Anuradha, Byun Jeman, Pennathur Subramaniam, Sana Theodore R, Fischer Steven M, Palapattu Ganesh S, Creighton Chad J, Michailidis George, Sreekumar Arun

Abstract excerpt

Prostate cancer is the second leading cause of cancer related death in American men. Development and progression of clinically localized prostate cancer is highly dependent on androgen signaling. Metastatic tumors are initially responsive to anti-androgen therapy, however become resistant to this regimen upon progression. Genomic and proteomic studies have implicated a role for androgen in regulating metabolic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21789170
DOI: 10.1371/journal.pone.0021417
PMCID: PMC3138744

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