Article
The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Mar 2012
Hubacek Jaroslav A, Viklicky Ondrej, Dlouha Dana, Bloudickova Silvie, Kubinova Ruzena, Peasey Anne, Pikhart Hynek, Adamkova Vera, Brabcova Irena, Pokorna Eva, Bobak Martin
Abstract excerpt
BACKGROUND: Genome-wide association studies identified the FTO (fat mass and obesity gene) gene as an important determinant of body weight. More recently, the FTO gene was reported to be associated with other outcomes, including major risk factors for chronic kidney disease (CKD). We investigated the role of this gene in the risk of end-stage renal disease (ESRD) caused by CKD. METHODS: We conducted two large...
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