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Article

The Genetic Associations Between Kidney Stones, Obesity, Type 2 Diabetes, and Hypertension.

Mayo Clinic proceedings - 1 Nov 2025

Zhou Le-Ting, Stark Isaac W, Ali Ahmed E, Jayachandran Muthuvel, Haskic Zejfa, Harris Peter C, Koo Kevin, McDonnell Shannon K, Larson Nicholas B, Lieske John C

Abstract excerpt

OBJECTIVE: Investigate shared genetic changes that contribute to the association of kidney stones with cardiometabolic comorbidities. PATIENTS AND METHODS: Genome-wide association studies (GWAS) and meta-analyses were performed using the UK Biobank, Mayo Clinic Biobank, and FinnGen, complemented by secondary genetic association analyses. RESULTS: Genetic correlation analyses confirmed modest but significant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40974350
DOI: 10.1016/j.mayocp.2025.04.030
PMCID: PMC12453589

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