Article
Molecular characterization and identification of surrogate substrates for diacylglycerol lipase α.
Biochemical and biophysical research communications - 12 Aug 2011
Pedicord Donna L, Flynn Michael J, Fanslau Caroline, Miranda Maricar, Hunihan Lisa, Robertson Barbara J, Pearce Bradley C, Yu Xuan-Chuan, Westphal Ryan S, Blat Yuval
Abstract excerpt
Diacylglycerol lipase α is the key enzyme in the formation of the most prevalent endocannabinoid, 2-arachidonoylglycerol in the brain. In this study we identified the catalytic triad of diacylglycerol lipase α, consisting of serine 472, aspartate 524 and histidine 650. A truncated version of diacylglycerol lipase α, spanning residues 1-687 retains complete catalytic activity suggesting that the C-terminal domain...
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