Article
Targeted enrichment beyond the consensus coding DNA sequence exome reveals exons with higher variant densities.
Genome biology - 25 Jul 2011
Bainbridge Matthew N, Wang Min, Wu Yuanqing, Newsham Irene, Muzny Donna M, Jefferies John L, Albert Thomas J, Burgess Daniel L, Gibbs Richard A
Abstract excerpt
BACKGROUND: Enrichment of loci by DNA hybridization-capture, followed by high-throughput sequencing, is an important tool in modern genetics. Currently, the most common targets for enrichment are the protein coding exons represented by the consensus coding DNA sequence (CCDS). The CCDS, however, excludes many actual or computationally predicted coding exons present in other databases, such as RefSeq and Vega, and...
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