Article
Improved canine exome designs, featuring ncRNAs and increased coverage of protein coding genes.
Scientific reports - 3 Aug 2015
Broeckx Bart J G, Hitte Christophe, Coopman Frank, Verhoeven Geert E C, De Keulenaer Sarah, De Meester Ellen, Derrien Thomas, Alfoldi Jessica, Lindblad-Toh Kerstin, Bosmans Tim, Gielen Ingrid, Van Bree Henri, Van Ryssen Bernadette, Saunders Jimmy H, Van Nieuwerburgh Filip, Deforce Dieter
Abstract excerpt
By limiting sequencing to those sequences transcribed as mRNA, whole exome sequencing is a cost-efficient technique often used in disease-association studies. We developed two target enrichment designs based on the recently released annotation of the canine genome: the exome-plus design and the exome-CDS design. The exome-plus design combines the exons of the CanFam 3.1 Ensembl annotation, more recently...
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