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Innate Inhibition of Adaptive Immunity: <i>Mycobacterium tuberculosis</i> -Induced IL-6 Inhibits Macrophage Responses to IFN-γ

1 Nov 2003

Abstract excerpt

In humans and in mice, control of the intracellular pathogen, Mycobacterium tuberculosis (Mtb), requires IFN-gamma. Although the adaptive immune response results in production of substantial amounts of IFN-gamma in response to Mtb, the immune response is unable to eradicate the infection in most cases. We have previously reported evidence that Mtb inhibits macrophage responses to IFN-gamma, suggesting that this...

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PMID: 14568951
DOI: 10.4049/jimmunol.171.9.4750

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