Article
Carbon monoxide promotes proliferation of uterine natural killer cells and remodeling of spiral arteries in pregnant hypertensive heme oxygenase-1 mutant mice.
Hypertension (Dallas, Tex. : 1979) - 1 Mar 2014
Linzke Nadja, Schumacher Anne, Woidacki Katja, Croy B Anne, Zenclussen Ana C
Abstract excerpt
Heme Oxygenase-1 (HO-1) and its metabolite carbon monoxide (CO) promote implantation and placentation. Pregnancy disorders such as preeclampsia and intrauterine growth restriction are linked to both HO-1 diminution and impaired remodeling of maternal spiral arteries (SAs). Here, we investigated whether CO is able to prevent preeclampsia and intrauterine growth restriction through the modulation of uterine natural...
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