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Article

Simplifying the detection of MUTYH mutations by high resolution melting analysis.

BMC cancer - 5 Aug 2010

López-Villar Isabel, Ayala Rosa, Wesselink Jan, Morillas Juan Diego, López Elena, Marín José Carlos, Díaz-Tasende José, González Sara, Robles Luis, Martínez-López Joaquín

Abstract excerpt

BACKGROUND: MUTYH-associated polyposis (MAP) is a disorder caused by bi-allelic germline MUTYH mutation, characterized by multiple colorectal adenomas. In order to identify mutations in MUTYH gene we applied High Resolution Melting (HRM) genotyping. HRM analysis is extensively employed as a scanning method for the detection of heterozygous mutations. Therefore, we applied HRM to show effectiveness in detecting...

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Source

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Identifiers

PMID: 20687945
DOI: 10.1186/1471-2407-10-408
PMCID: PMC2924853

Genes

MUTYH
APC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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