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Article

High chromosome number in hematological cancer cell lines is a negative predictor of response to the inhibition of Aurora B and C by GSK1070916.

Journal of translational medicine - 15 Jul 2011

Moy Christopher, Oleykowski Catherine A, Plant Ramona, Greshock Joel, Jing Junping, Bachman Kurtis, Hardwicke Mary Ann, Wooster Richard, Degenhardt Yan

Abstract excerpt

BACKGROUND: Aurora kinases play critical roles in mitosis and are being evaluated as therapeutic targets in cancer. GSK1070916 is a potent, selective, ATP competitive inhibitor of Aurora kinase B and C. Translation of predictive biomarkers to the clinic can benefit patients by identifying the tumors that are more likely to respond to therapies, especially novel inhibitors such as GSK1070916. METHODS: 59...

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Identifiers

PMID: 21762492
DOI: 10.1186/1479-5876-9-110
PMCID: PMC3146841

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NOTCH1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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