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Article

Pathway-based association analyses identified TRAIL pathway for osteoporotic fractures.

PloS one - 1 Jan 2011

Zhang Yin-Ping, Liu Yao-Zhong, Guo Yan, Liu Xiao-Gang, Xu Xiang-Hong, Guo Yan-Fang, Chen Yuan, Zhang Feng, Pan Feng, Zhu Xue-Zhen, Deng Hong-Wen

Abstract excerpt

INTRODUCTION: Hip OF carries the highest morbidity and mortality. Previous studies revealed that individual genes/loci in the Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) pathway were associated with bone metabolism. This study aims to verify the potential association between hip OF and TRAIL pathway. METHODS: Using genome-wide genotype data from Affymetrix 500 K SNP arrays, we performed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 21760914
DOI: 10.1371/journal.pone.0021835
PMCID: PMC3132733

Genes

TNFSF10
CFLAR
NFKB1
TNF
TNFSF11
TRAF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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