Article
Genetic variation in the HR region of the env gene of HIV: A perspective for resistance to HIV fusion inhibitors.
AIDS research and human retroviruses - 1 Jan 2011
Qadir M I, Malik S A
Abstract excerpt
HIV fusion inhibitors may be classified into three groups. Peptides binding to HR1 include T1249, C30, and T20 (enfuvirtide). Peptides binding to HR2 include 5-helix. XTT formazan, NB-2, and NB-64 are nonpeptide fusion inhibitors. Genotypic testing for drug resistance is used more commonly than phenotypic testing because of its lower cost, wider availability, and shorter turnaround time. The aim of the study was...
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