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Article

Heightened induction of proapoptotic signals in response to endoplasmic reticulum stress in primary fibroblasts from a mouse model of longevity.

The Journal of biological chemistry - 2 Sept 2011

Sadighi Akha Amir A, Harper James M, Salmon Adam B, Schroeder Bethany A, Tyra Heather M, Rutkowski D Thomas, Miller Richard A

Abstract excerpt

Previous work from our laboratory has shown that primary fibroblasts from long-lived Snell dwarf mice display a higher sensitivity to the lethal effects of endoplasmic reticulum (ER) stressors, such as thapsigargin, than cells from normal mice. Here we show that thapsigargin induces higher expression of CHOP, enhanced cleavage of caspase-12, higher caspase-3 activity, and increased phosphorylation of c-JUN, all...

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Topics

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Share to Caenorhabditis elegans Proteins
Share to Endoplasmic Reticulum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Longevity

Share to Mice, Inbred C3H

Share to Pituitary Gland

Share to Protein Denaturation

Share to Receptor, Insulin

Share to Transcription Factor CHOP

Source

Open in PubMed Open full text

Identifiers

PMID: 21757703
DOI: 10.1074/jbc.M111.220541
PMCID: PMC3162393

Genes

XBP1
JUN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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