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Characterizing age-related changes in intact mitochondrial proteoforms in murine hearts using quantitative top-down proteomics

29 Sept 2024

Abstract excerpt

BACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and the prevalence of CVDs increases markedly with age. Due to the high energetic demand, the heart is highly sensitive to mitochondrial dysfunction. The complexity of the cardiac mitochondrial proteome hinders the development of effective strategies that target mitochondrial dysfunction in CVDs. Mammalian mitochondria are...

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PMID: 39343872
DOI: 10.1186/s12014-024-09509-1

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