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Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses

11 Feb 2008

Abstract excerpt

Transferrin receptor 1 (TfR1) is a cellular receptor for the New World hemorrhagic fever arenaviruses Machupo (MACV), Junín (JUNV), and Guanarito (GTOV). Each of these viruses is specifically adapted to a distinct rodent host species, but all cause human disease. Here we compare the ability of these viruses to use various mammalian transferrin receptor 1 (TfR1) orthologs, including those of the South American...

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PMID: 18268337
DOI: 10.1073/pnas.0709254105

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