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Article

Salmonella enterica Serotype Typhi with nonclassical quinolone resistance phenotype.

Emerging infectious diseases - 1 Jun 2011

Accou-Demartin Marie, Gaborieau Valérie, Song Yajun, Roumagnac Philippe, Marchou Bruno, Achtman Mark, Weill François-Xavier

Abstract excerpt

We report Salmonella enterica serotype Typhi strains with a nonclassical quinolone resistance phenotype (i.e., decreased susceptibility to ciprofloxacin but with susceptibility to nalidixic acid) associated with a nonsynonymous mutation at codon 464 of the gyrB gene. These strains, not detected by the nalidixic acid disk screening test, can result in fluoroquinolone treatment failure.

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Identifiers

PMID: 21749778
DOI: 10.3201/eid/1706.101242
PMCID: PMC3358197

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