Article
An intronic polymorphism in the porcine IRF7 gene is associated with better health and immunity of the host during Sarcocystis infection, and affects interferon signalling.
Animal genetics - 1 Aug 2011
Brock A J, Broke A, Matika O, Wilson A D, Anderson J, Morin A-C, Finlayson H A, Reiner G, Willems H, Bishop S C, Archibald A L, Ait-Ali T
Abstract excerpt
Interferon regulatory factor 7 (IRF7), as a key regulator of type I interferon response, plays an important role during innate response against viral infection. Although well conserved across species, the structure of IRF7 and its function during parasite infection are not well documented in farm animals, such as the pig. To bridge this gap, we have determined the porcine IRF7 gene structure and identified two...
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