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Article

Two coupled mutations abolished the binding of CEBPB to the promoter of CXCL14 that displayed an antiviral effect on PRRSV by activating IFN signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2020

Niu Lizhu, Zheng Zhiwei, Xue Qianjing, Cheng Huijun, Liu Ying, Wang Huanling, Hu Xueying, Zhang Anding, Liu Bang, Xu Xuewen

Abstract excerpt

Porcine reproductive and respiratory syndrome (PRRS) is the most economically important infectious disease of pigs worldwide. Our previous study revealed that Tongcheng (TC) pigs display higher resistance to PRRS than Largewhite (LW) pigs, but the genetic mechanism remains unknown. Here, we first confirmed that CXCL14 was downregulated in lungs and porcine alveolar macrophages (PAMs) responding to PRRS virus...

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Identifiers

PMID: 32648265
DOI: 10.1096/fj.202000477R

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