Article
PPARGC1B gene is associated with Kashin-Beck disease in Han Chinese.
Functional & integrative genomics - 1 Jul 2016
Wen Yan, Hao Jingcan, Xiao Xiao, Wang Wenyu, Guo Xiong, Lin Weimin, Yang Tielin, Liu Xiaogang, Shen Hui, Tan Lijun, Chen Xiangding, Tian Qing, Deng Hong-Wen, Zhang Feng
Abstract excerpt
Kashin-Beck disease (KBD) is a chronic osteochondropathy. The genetic basis of KBD remains elusive now. To investigate the relationship between PPARGC1B gene polymorphism and KBD, we conducted a two-stage association study using 2743 unrelated Han Chinese subjects. In the first stage, three SNPs rs1078324, rs4705372, and rs11743128 of PPARGC1B gene were genotyped in 559 KBD patients and 467 health controls using...
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