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Article

Key amino acid residues of ankyrin-sensitive phosphatidylethanolamine/phosphatidylcholine-lipid binding site of βI-spectrin.

PloS one - 1 Jan 2011

Wolny Marcin, Grzybek Michał, Bok Ewa, Chorzalska Anna, Lenoir Marc, Czogalla Aleksander, Adamczyk Klaudia, Kolondra Adam, Diakowski Witold, Overduin Michael, Sikorski Aleksander F

Abstract excerpt

It was shown previously that an ankyrin-sensitive, phosphatidylethanolamine/phosphatidylcholine (PE/PC) binding site maps to the N-terminal part of the ankyrin-binding domain of β-spectrin (ankBDn). Here we have identified the amino acid residues within this domain which are responsible for recognizing monolayers and bilayers composed of PE/PC mixtures. In vitro binding studies revealed that a quadruple mutant...

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PMID: 21738695
DOI: 10.1371/journal.pone.0021538
PMCID: PMC3125217

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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