Article
Mapping of an ankyrin-sensitive, phosphatidylethanolamine/phosphatidylcholine mono- and bi-layer binding site in erythroid beta-spectrin.
The Biochemical journal - 1 Sept 2004
Hryniewicz-Jankowska Anita, Bok Ewa, Dubielecka Patrycja, Chorzalska Anna, Diakowski Witold, Jezierski Adam, Lisowski Marek, Sikorski Aleksander F
Abstract excerpt
It has been shown previously that binding of vesicles and monolayers containing PE (phosphatidylethanolamine) by either erythroid or non-erythroid spectrin proved sensitive to inhibition by purified erythrocyte ankyrin. We tested the lipid-binding affinities of the purified ankyrin-binding domain of beta-spectrin and of its truncated mutants in four ways, by analysing: (1) penetration of 'loose' PE/PC...
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