Article
The C-terminal transmembrane domain of human phospholipid scramblase 1 is essential for the protein flip-flop activity and Ca²⁺-binding.
The Journal of membrane biology - 1 Feb 2014
Sánchez-Magraner Lissete, Posada Itziar M D, Andraka Nagore, Contreras F Xabier, Viguera Ana R, Guérin Diego M A, Arrondo José L R, Monaco Hugo L, Goñi Félix M
Abstract excerpt
Human phospholipid scramblase 1 (SCR) is a 318 amino acid protein that was originally described as catalyzing phospholipid transbilayer (flip-flop) motion in plasma membranes in a Ca²⁺-dependent, ATP-independent way. Further studies have suggested an intranuclear role for this protein in addition. A putative transmembrane domain located at the C terminus (aa 291-309) has been related to the flip-flop catalysis....
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