Article
Overexpression of Lis1 in different stages of spermatogenesis does not result in an aberrant phenotype.
Cytogenetic and genome research - 1 Jan 2011
Drusenheimer N, Nayernia K, Meinhardt A, Jung B, Arnold H-H, Engel W
Abstract excerpt
Previous studies showed that in the mouse mutant Lis1(GT/GT) gene trap integration in intron 2 of Lis1 gene leads to male infertility in homozygous Lis1(GT/GT) mice. We further analyzed this line and could confirm the suggested downregulation of a testis-specific Lis1 transcript in mutant animals in a quantitative manner. Moreover, we analyzed the gene trap mutation on different genetic backgrounds in incipient...
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