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MET amplification identified by next-generation sequencing and its clinical relevance for MET inhibitors

10 Nov 2021

Abstract excerpt

BACKGROUND: MET amplification plays an important role in the development of non-small-cell lung cancer (NSCLC) either de novo or in resistance to epidermal growth factor receptor tyrosine-kinase inhibitor (EGFR-TKI) settings. Fluorescence in situ hybridization (FISH) is the standard method for MET amplification. With more and more discoveries of oncogenic driver genes, next-generation sequencing (NGS) plays a...

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PMID: 34758872
DOI: 10.1186/s40164-021-00245-y

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