Article
Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer.
Cancer science - 1 Nov 2008
Okuda Katsuhiro, Sasaki Hidefumi, Yukiue Haruhiro, Yano Motoki, Fujii Yoshitaka
Abstract excerpt
The Met oncogene encodes the tyrosine kinase receptor for hepatocyte growth factor (HGF). Uncontrolled activation of Met is oncogenic and has been implicated in the growth, invasion and metastasis in a variety of tumors. Several distinct mechanisms including amplification, translocation or mutation of Met may underlie uncontrolled Met activation. In several solid tumors, amplification and mutation of Met were...
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