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Article

Genome-wide association study identifies ITPR2 as a susceptibility gene for Kashin-Beck disease in Han Chinese.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jan 2015

Zhang Feng, Wen Yan, Guo Xiong, Zhang Yingang, Wang Xi, Yang Tielin, Shen Hui, Chen Xiangding, Tian Qing, Deng Hong-Wen

Abstract excerpt

OBJECTIVE: Kashin-Beck disease (KBD) is a chronic osteochondropathy, the pathogenesis of which remains elusive. The aim of this study was to identify susceptibility genes for KBD by conducting a 2-stage genome-wide association study (GWAS). METHODS: Ninety patients with grade II or grade III KBD with extreme KBD phenotypes and 1,627 healthy control subjects were enrolled in the initial GWAS. Affymetrix...

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Identifiers

PMID: 25303641
DOI: 10.1002/art.38898

Genes

ITPR2

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