Article
Identification of a human immunodeficiency virus type 1 envelope glycoprotein variant resistant to cold inactivation.
Journal of virology - 1 May 2009
Kassa Aemro, Finzi Andrés, Pancera Marie, Courter Joel R, Smith Amos B, Sodroski Joseph
Abstract excerpt
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein trimer consists of gp120 and gp41 subunits and undergoes a series of conformational changes upon binding to the receptors, CD4 and CCR5/CXCR4, that promote virus entry. Surprisingly, we found that the envelope glycoproteins of...
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