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Article

The IMD innate immunity pathway of Drosophila influences somatic sex determination via regulation of the Doa locus.

Developmental biology - 15 Nov 2015

Zhao Yunpo, Cocco Claudia, Domenichini Severine, Samson Marie-Laure, Rabinow Leonard

Abstract excerpt

The IMD pathway induces the innate immune response to infection by gram-negative bacteria. We demonstrate strong female-to-male sex transformations in double mutants of the IMD pathway in combination with Doa alleles. Doa encodes a protein kinase playing a central role in somatic sex determination through its regulation of alternative splicing of dsx transcripts. Transcripts encoding two specific Doa isoforms are...

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Identifiers

PMID: 26434917
DOI: 10.1016/j.ydbio.2015.09.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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