Article
MUC1 and MUC4: switching the emphasis from large to small.
Cancer biotherapy & radiopharmaceuticals - 1 Jun 2011
Albrecht Huguette, Carraway Kermit L
Abstract excerpt
The MUC1 and MUC4 membrane mucins are each composed of a large alpha (α) and a small beta (β) subunit. The α subunits are fully exposed at the cell surface and contain variable numbers of repeated amino acid sequences that are heavily glycosylated. In contrast, the β subunits are much smaller and are anchored within the cell membrane, with their amino-terminal portions exposed at the cell surface and their...
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