Overexpression of the MPO gene occurring in a case of APL without unusual genotypic characteristics.

doi:10.1016/0145-2126(90)90065-h

Article

Overexpression of the MPO gene occurring in a case of APL without unusual genotypic characteristics.

Leukemia research - 1 Jan 1990

Ferrari S, Tagliafico E, Temperani P, Manfredini R, Ceccherelli G, Zucchini P, Tabilio A, Donelli A, Torelli G, Emilia G

Abstract excerpt

Northern blot analysis of four typical cases of acute promyelocytic leukemia showed that one of the cell population examined was characterized by a very high level of expression of the myeloperoxidase (MPO) gene. Western blot analysis confirms that the protein content of the cells corresponded to...

Topics

Blotting, Southern
Blotting, Western
Chromosomes, Human, Pair 17
Genotype
Humans
Leukemia, Promyelocytic, Acute
Peroxidase
RNA, Messenger
Translocation, Genetic

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