Article
Overexpression of the MPO gene occurring in a case of APL without unusual genotypic characteristics.
Leukemia research - 1 Jan 1990
Ferrari S, Tagliafico E, Temperani P, Manfredini R, Ceccherelli G, Zucchini P, Tabilio A, Donelli A, Torelli G, Emilia G
Abstract excerpt
Northern blot analysis of four typical cases of acute promyelocytic leukemia showed that one of the cell population examined was characterized by a very high level of expression of the myeloperoxidase (MPO) gene. Western blot analysis confirms that the protein content of the cells corresponded to the levels of the MPO mRNA. Southern blot studies of the DNA of this cell population ruled out the presence of any...
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