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Article

A Transcriptional Roadmap to the Senescence and Differentiation of Human Oral Keratinocytes

7 Jan 2014

Abstract excerpt

Human epithelial cells undergo morphological and molecular changes leading to terminal differentiation and replicative senescence after a finite number of cell divisions during serial subculture. However, the target genes and their functional significance in the senescence and differentiation in normal human oral keratinocytes have been poorly defined. Here, we demonstrated normal human oral keratinocytes...

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PMID: 24398559
DOI: 10.1093/gerona/glt212

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