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Article

p63–microRNA feedback in keratinocyte senescence

6 Jan 2012

Abstract excerpt

We investigated the expression of microRNAs (miRNAs) associated with replicative senescence in human primary keratinocytes. A cohort of miRNAs up-regulated in senescence was identified by genome-wide miRNA profiling, and their change in expression was validated in proliferative versus senescent cells. Among these, miRNA (miR)-138, -181a, -181b, and -130b expression increased with serial passages. miR-138, -181a,...

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PMID: 22228303
DOI: 10.1073/pnas.1112257109

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