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Article

The mTOR/AKT inhibitor temsirolimus prevents deep infiltrating endometriosis in mice.

The American journal of pathology - 1 Aug 2011

Leconte Mahaut, Nicco Carole, Ngô Charlotte, Chéreau Christiane, Chouzenoux Sandrine, Marut Wioleta, Guibourdenche Jean, Arkwright Sylviane, Weill Bernard, Chapron Charles, Dousset Bertrand, Batteux Frédéric

Abstract excerpt

Deep infiltrating endometriosis (DIE) is a particular clinical and histological entity of endometriosis responsible for chronic pelvic pain and infertility. Here we characterize the proliferative phenotype of DIE cells, to explore the cellular and molecular mechanisms that could explain their aggressive potential. In addition, the inhibition of mTOR/AKT pathway was tested, as a potential treatment of DIE....

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Identifiers

PMID: 21718677
DOI: 10.1016/j.ajpath.2011.04.020
PMCID: PMC3157265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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