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Article

Macrophage-associated immune checkpoint CD47 blocking ameliorates endometriosis

11 Apr 2022

Abstract excerpt

Peritoneal macrophages play a significant role in the progression of endometriosis (EM), but their functional differentiation is still unclear, and their phagocytic ability is weak. CD47-signal-regulated protein α (SIRPα) and PD-L1-PD-1 are considered immune checkpoints associated with macrophage phagocytosis. A specific blockade of these two pathways had been shown to increase the phagocytic clearance of cancer...

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PMID: 35404426
DOI: 10.1093/molehr/gaac010

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