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Article

Genetic variants of the p53 and p73 genes jointly increase risk of second primary malignancies in patients after index squamous cell carcinoma of the head and neck.

Cancer - 15 Jan 2012

Zhang Yang, Sturgis Erich M, Huang Zhigang, Zafereo Mark E, Wei Qingyi, Li Guojun

Abstract excerpt

BACKGROUND: Because of the structural and biochemical similarities between the antitumor p53 and p73 proteins, the authors hypothesized that individuals who carry high-risk genotypes of p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms have a higher risk of developing second primary malignancy (SPM) after index squamous cell carcinoma of the head and neck (SCCHN). METHODS: A cohort of 1269 patients with index...

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Share to Carcinoma, Squamous Cell
Share to Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Neoplasms, Second Primary

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Share to Squamous Cell Carcinoma of Head and Neck

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Source

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Identifiers

PMID: 21717430
DOI: 10.1002/cncr.26222
PMCID: PMC3184342

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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