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Article

Genetic variants in p53-related genes confer susceptibility to second primary malignancy in patients with index squamous cell carcinoma of head and neck.

Carcinogenesis - 1 Jul 2013

Jin Lei, Sturgis Erich M, Zhang Yang, Huang Zhigang, Wei Peng, Guo Wei, Wang Zhongqiu, Wei Qingyi, Song Xicheng, Li Guojun

Abstract excerpt

Because of their important roles in mediating the stabilization and expression of p53, we hypothesized that high-risk genotypes of polymorphisms in p53-related genes, including p53, p73, p14(ARF), MDM2 and MDM4, may be associated with an increased risk of second primary malignancy (SPM) after index squamous cell carcinoma of the head and neck (SCCHN). We analyzed data from a cohort of 1283 patients with index...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23508638
DOI: 10.1093/carcin/bgt096
PMCID: PMC3697893

Genes

MDM2
MDM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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