Article
Mitochondrial-targeted Signal transducer and activator of transcription 3 (STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species.
The Journal of biological chemistry - 26 Aug 2011
Szczepanek Karol, Chen Qun, Derecka Marta, Salloum Fadi N, Zhang Qifang, Szelag Magdalena, Cichy Joanna, Kukreja Rakesh C, Dulak Jozef, Lesnefsky Edward J, Larner Andrew C
Abstract excerpt
Expression of the STAT3 transcription factor in the heart is cardioprotective and decreases the levels of reactive oxygen species. Recent studies indicate that a pool of STAT3 resides in the mitochondria where it is necessary for the maximal activity of complexes I and II of the electron transport chain. However, it has not been explored whether mitochondrial STAT3 modulates cardiac function under conditions of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.