Article
Mitochondrial-targeted Signal transducer and activator of transcription 3 (STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species.
The Journal of biological chemistry - 26 Aug 2011
Szczepanek Karol, Chen Qun, Derecka Marta, Salloum Fadi N, Zhang Qifang, Szelag Magdalena, Cichy Joanna, Kukreja Rakesh C, Dulak Jozef, Lesnefsky Edward J, Larner Andrew C
Abstract excerpt
Expression of the STAT3 transcription factor in the heart is cardioprotective and decreases the levels of reactive oxygen species. Recent studies indicate that a pool of STAT3 resides in the mitochondria where it is necessary for the maximal activity of complexes I and II of the electron transpor...
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