Article
Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro.
PloS one - 10 Mar 2010
Sarafian Theodore A, Montes Cindy, Imura Tetsuya, Qi Jingwei, Coppola Giovanni, Geschwind Daniel H, Sofroniew Michael V
Abstract excerpt
BACKGROUND: Astrocytes exert a wide variety of functions in health and disease and respond to a wide range of signaling pathways, including members of the Janus-kinase signal transducers and activators of transcription (Jak-STAT) family. We have recently shown that STAT3 is an important regulator...
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