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A renal cell carcinoma tumorgraft platform to advance precision medicine

1 Nov 2021

Abstract excerpt

Renal cell carcinoma (RCC) encompasses a heterogenous group of tumors, but representative preclinical models are lacking. We previously showed that patient-derived tumorgraft (TG) models recapitulate the biology and treatment responsiveness. Through systematic orthotopic implantation of tumor samples from 926 ethnically diverse individuals into non-obese diabetic (NOD)/severe combined immunodeficiency (SCID)...

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Cancer Genomics and Diagnostics
Epigenetics and DNA Methylation
Renal cell carcinoma treatment

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34818533
DOI: 10.1016/j.celrep.2021.110055

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