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Article

Plastin 3 ameliorates spinal muscular atrophy via delayed axon pruning and improves neuromuscular junction functionality.

Human molecular genetics - 1 Apr 2013

Ackermann Bastian, Kröber Sandra, Torres-Benito Laura, Borgmann Anke, Peters Miriam, Hosseini Barkooie Seyyed Mohsen, Tejero Rocio, Jakubik Miriam, Schreml Julia, Milbradt Janine, Wunderlich Thomas F, Riessland Markus, Tabares Lucia, Wirth Brunhilde

Abstract excerpt

F-actin bundling plastin 3 (PLS3) is a fully protective modifier of the neuromuscular disease spinal muscular atrophy (SMA), the most common genetic cause of infant death. The generation of a conditional PLS3-over-expressing mouse and its breeding into an SMA background allowed us to decipher the exact biological mechanism underlying PLS3-mediated SMA protection. We show that PLS3 is a key regulator that restores...

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Share to Evoked Potentials, Motor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23263861
DOI: 10.1093/hmg/dds540

Genes

PLS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Plastin 3 ameliorates spinal muscular atrophy via delayed axon pruning and improves neuromuscular junction functionality.PMID 23263861Read ↗

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