Article
Using regulatory and epistatic networks to extend the findings of a genome scan: identifying the gene drivers of pigmentation in merino sheep.
PloS one - 1 Jan 2011
García-Gámez Elsa, Reverter Antonio, Whan Vicki, McWilliam Sean M, Arranz Juan José, Kijas James
Abstract excerpt
Extending genome wide association analysis by the inclusion of gene expression data may assist in the dissection of complex traits. We examined piebald, a pigmentation phenotype in both human and Merino sheep, by analysing multiple data types using a systems approach. First, a case control analysis of 49,034 ovine SNP was performed which confirmed a multigenic basis for the condition. We combined these results...
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