Combined pathway-based biomarker discovery and ESR2 gene, polymorphism analysis of litter size prediction in sheep using a, multi model bioinformatics toolbox.

doi:10.1016/j.anireprosci.2025.108090

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Combined pathway-based biomarker discovery and ESR2 gene, polymorphism analysis of litter size prediction in sheep using a, multi model bioinformatics toolbox.

Animal reproduction science - 1 Mar 2026

Javanmard Arash, Yazdanyar Mansour, Ebrahimi Mahdi, Rafat Abbas, Hasanpur Karim, Panahi Babak Ghasemi, Alijani Sadegh, Cheraghi Habib, Sheikhlou Mohammadreza, Mohammadabadi Mohammadreza, Esmailizadeh Ali

Abstract excerpt

By utilizing a comprehensive multi-modal approach that combined in silico modeling, in vitro molecular assays, in vivo microscopic observations, and on-farm phenotyping, we aimed to improve comprehension of the genetic architecture related to sheep litter size (LS). Our goal was to assess a T/C polymorphism (rs423810437) in the ovine Estrogen Receptor 2 (ESR2) gene and find potential LS biomarkers by applying...

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Identifiers

PMID: 41442814
DOI: 10.1016/j.anireprosci.2025.108090

Genes

ESR2
BMPR1B
GDF9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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