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Article

BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex.

Nature neuroscience - 1 Jun 2006

Kleim Jeffrey A, Chan Sheila, Pringle Erin, Schallert Kellan, Procaccio Vincent, Jimenez Richard, Cramer Steven C

Abstract excerpt

Motor training can induce profound physiological plasticity within primary motor cortex, including changes in corticospinal output and motor map topography. Using transcranial magnetic stimulation, we show that training-dependent increases in the amplitude of motor-evoked potentials and motor map...

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Source

Identifiers

PMID: 16680163
DOI: 10.1038/nn1699

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16680163-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex.PMID 16680163Read ↗

Differential modulation of motor cortex excitability in BDNF Met allele carriers following experimentally induced and use-dependent plasticity.Semantic proximity Read ↗

Intense training overcomes effects of the Val66Met BDNF polymorphism on short-term plasticity.Semantic proximity Read ↗

A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS.Semantic proximity Read ↗

Interaction of BDNF and COMT polymorphisms on paired-associative stimulation-induced cortical plasticity.Semantic proximity Read ↗

The BDNF val(66)met polymorphism is not related to motor function or short-term cortical plasticity in elderly subjects.Semantic proximity Read ↗

BDNF val66met polymorphism influences motor system function in the human brain.Semantic proximity Read ↗

Val66Met in brain-derived neurotrophic factor affects stimulus-induced plasticity in the human pharyngeal motor cortex.Semantic proximity Read ↗

BDNF Val66Met polymorphism is associated with abnormal interhemispheric transfer of a newly acquired motor skill.Semantic proximity Read ↗

Correlation between cortical plasticity, motor learning and BDNF genotype in healthy subjects.Semantic proximity Read ↗

Influence of BDNF Val66Met polymorphism on excitatory-inhibitory balance and plasticity in human motor cortex.Semantic proximity Read ↗

Val66Met BDNF gene polymorphism influences human motor cortex plasticity in acute stroke.Semantic proximity Read ↗

Late cortical plasticity in motor and auditory cortex: role of met-allele in BDNF Val66Met polymorphism.Semantic proximity Read ↗

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