Article
bop5 Mutations reveal new roles for the IC138 phosphoprotein in the regulation of flagellar motility and asymmetric waveforms.
Molecular biology of the cell - 15 Aug 2011
VanderWaal Kristyn E, Yamamoto Ryosuke, Wakabayashi Ken-ichi, Fox Laura, Kamiya Ritsu, Dutcher Susan K, Bayly Phillip V, Sale Winfield S, Porter Mary E
Abstract excerpt
I1 dynein, or dynein f, is a highly conserved inner arm isoform that plays a key role in the regulation of flagellar motility. To understand how the IC138 IC/LC subcomplex modulates I1 activity, we characterized the molecular lesions and motility phenotypes of several bop5 alleles. bop5-3, bop5-4, and bop5-5 are null alleles, whereas bop5-6 is an intron mutation that reduces IC138 expression. I1 dynein assembles...
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