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Article

Epigenetic Dysregulation in Mesenchymal Stem Cell Aging and Spontaneous Differentiation

9 Jun 2011

Abstract excerpt

BACKGROUND: Mesenchymal stem cells (MSCs) hold great promise for the treatment of difficult diseases. As MSCs represent a rare cell population, ex vivo expansion of MSCs is indispensable to obtain sufficient amounts of cells for therapies and tissue engineering. However, spontaneous differentiation and aging of MSCs occur during expansion and the molecular mechanisms involved have been poorly understood....

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PMID: 21694780
DOI: 10.1371/journal.pone.0020526

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