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Article

Lumican Peptides: Rational Design Targeting ALK5/TGFBRI

9 Feb 2017

Abstract excerpt

Lumican, a small leucine rich proteoglycan (SLRP), is a component of extracellular matrix which also functions as a matrikine regulating multiple cell activities. In the cornea, lumican maintains corneal transparency by regulating collagen fibrillogenesis, promoting corneal epithelial wound healing, regulating gene expression and maintaining corneal homeostasis. We have recently shown that a peptide designed from...

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PMID: 28181591
DOI: 10.1038/srep42057

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